Basic Information
VIS ID
TVIS30001257
Fusion event
HIV-GCN1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
120626829/120189026 (Hg38)
End
120626950/120189026 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
GCN1
miRNAs that regulate target gene
hsa-mir-1293 ; hsa-mir-1226-3p ; hsa-mir-18a-3p ; hsa-mir-484 ; hsa-mir-425-3p ; hsa-mir-423-3p ; hsa-mir-328-3p ; hsa-mir-185-5p ; hsa-mir-149-5p ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-let-7b-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-let-7i/Upstream/33527; hsa-mir-3612/Downstream/534167;
Nearest TSS
ENST00000382841/Upstream/11236; ENST00000538804/Downstream/5684;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/71606, chr12-CpG: 66/Downstream/5393
Target sequence
TAAAGTAAAGGCAGAAGTTGTGCAGGGAGGGGGGAAGAAGGCCATGGTTCCTTTTTTATTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGCACGATCTCAGCTCACTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate