Basic Information
VIS ID
TVIS30001258
Fusion event
HIV-GLCCI1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
8054365/8014735 (Hg38)
End
8055245/8014735 (Hg38)
Orient
-
Location type
Intronic
Target gene
GLCCI1
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-335-5p ; hsa-mir-192-5p ; hsa-mir-550b-2-5p ; hsa-mir-5590-5p ; hsa-mir-1227-3p ; hsa-mir-5580-3p ; hsa-mir-8485 ; hsa-mir-4443 ; hsa-mir-650 ; hsa-mir-7847-3p ; hsa-mir-3612 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-129-5p ; hsa-mir-153-5p ; hsa-mir-297 ; hsa-mir-3149 ; hsa-mir-33a-5p ; hsa-mir-33b-5p ; hsa-mir-3680-3p ; hsa-mir-450b-5p ; hsa-mir-507 ; hsa-mir-557 ; hsa-mir-675-3p
Nearest miRNA
hsa-mir-339/Upstream/947690; hsa-mir-10399/Downstream/10112485;
Nearest TSS
ENST00000635602/Upstream/10838; ENST00000496617/Downstream/40772;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/44871, chr7-CpG: 118/Downstream/246666
Target sequence
CTATTCAACTCTAGGATTCTACAATCCTCTGTCTCATAATTAGATGATGGCTGAGAGAAAAAGTAAAGGTGATCTCAACAGCCAGTCAGGGGCCAGCTCCATAAAAAATAATTTAGACCCCTAGAATGCAATCTAAGAGGCAAAAACAGTCAAATCTTCAGTCTTGCTTCCATTTCATGAAGAAGTCCCCCAGCCCCTAAAATGTTTCAGCAACTGCTGTTTCTTAAATATATTTCAAAAGCAAGCCCTTTGACA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate