Basic Information
VIS ID
TVIS30001260
Fusion event
HIV-GRIP1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
66740885/66347105 (Hg38)
End
66741334/66347105 (Hg38)
Orient
+
Location type
Intronic
Target gene
GRIP1
Nearest miRNA
hsa-let-7i/Upstream/95948; hsa-mir-1178/Downstream/2926052;
Nearest TSS
ENST00000382841/Upstream/24365; ENST00000539109/Downstream/25236;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/111481, chr12-CpG: 105/Downstream/721785
Target sequence
GAGGCCAAGGCGGGTGGATCACTTGAGGTCACGAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATGTCTACTAAAAAA:TACAAAAACTAGCCAGGTGTGGTGGCGGGTGCCTGTAATCCCAGATACTTGGGAAACTGAGGTAGGAGAATCACTTGAGCCCCGGAGGCAGGGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGTGAAACTCCATCATCATCTCAAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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