Basic Information
VIS ID
TVIS30001262
Fusion event
HIV-HEMGN integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
100697831/97935549 (Hg38)
End
100698744/97935549 (Hg38)
Orient
-
Location type
Intronic
Target gene
HEMGN
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-1287-3p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-let-7a-1/Upstream/571868; hsa-mir-12126/Downstream/293600;
Nearest TSS
ENST00000422679/Upstream/12979; ENST00000473205/Downstream/2844;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/12780, chr9-CpG: 276/Downstream/47151
Target sequence
CCTTTTCATTCAAAAACATTTGCTGAATGTCTGCTTCCAGGCTTTCTCTGGAGATACAAGGATAAATGAGATGCAGTCCTTGTCCTCAAAAAGCTAGGAGAAAAACCTAGAACAGAGACTCTGCCACTTGGCTACAGGACTTTTGCTGATAGACACCACAGTTCATCACTTTTTCTAATCACTTTCATTTTATTACAGAAGTCATTGGAACCTGGAGTTTGAGAAACAGAGAACTACTTAGAAAAAGAAAAGCTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate