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TVIS30001265
Basic Information
VIS ID
TVIS30001265
Fusion event
HIV-IL6ST integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
55283736/55987908 (Hg38)
End
55283975/55987908 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
IL6ST
miRNAs that regulate target gene
hsa-mir-590-3p
;
hsa-mir-335-5p
;
hsa-mir-215-5p
;
hsa-mir-192-5p
;
hsa-mir-615-3p
;
hsa-mir-190a-3p
;
hsa-mir-5011-5p
;
hsa-mir-302c-3p
;
hsa-mir-512-3p
;
hsa-mir-4501
;
hsa-mir-25-3p
;
hsa-mir-32-5p
;
hsa-mir-92a-3p
;
hsa-mir-363-3p
;
hsa-mir-367-3p
;
hsa-mir-92b-3p
;
hsa-mir-4789-5p
;
hsa-mir-6074
;
hsa-mir-4729
;
hsa-mir-4661-5p
;
hsa-mir-559
;
hsa-mir-548b-5p
;
hsa-mir-548a-5p
;
hsa-mir-548c-5p
;
hsa-mir-548d-5p
;
hsa-mir-548j-5p
;
hsa-mir-548h-5p
;
hsa-mir-548i
;
hsa-mir-548w
;
hsa-mir-548y
;
hsa-mir-548o-5p
;
hsa-mir-548ab
;
hsa-mir-548ad-5p
;
hsa-mir-548ae-5p
;
hsa-mir-548ak
;
hsa-mir-548am-5p
;
hsa-mir-548ap-5p
;
hsa-mir-548aq-5p
;
hsa-mir-548ar-5p
;
hsa-mir-548as-5p
;
hsa-mir-548au-5p
;
hsa-mir-548ay-5p
;
hsa-mir-548bb-5p
;
hsa-mir-4650-3p
;
hsa-mir-1303
;
hsa-mir-5589-3p
;
hsa-mir-4272
;
hsa-mir-548p
;
hsa-mir-3924
;
hsa-mir-4473
;
hsa-mir-6073
;
hsa-mir-4720-3p
;
hsa-mir-4804-3p
;
hsa-mir-4328
;
hsa-mir-7852-3p
;
hsa-mir-6507-3p
;
hsa-mir-8054
;
hsa-mir-548l
;
hsa-mir-548k
;
hsa-mir-548av-5p
;
hsa-mir-223-3p
;
hsa-mir-142-3p
;
hsa-mir-520f-3p
;
hsa-mir-1277-5p
;
hsa-mir-6867-5p
;
hsa-mir-223-5p
;
hsa-mir-190b
;
hsa-mir-190a-5p
;
hsa-mir-511-3p
;
hsa-mir-4766-3p
;
hsa-mir-3941
;
hsa-mir-3908
;
hsa-mir-4703-5p
;
hsa-mir-3942-5p
;
hsa-mir-603
;
hsa-mir-362-3p
;
hsa-mir-329-3p
;
hsa-mir-8485
;
hsa-mir-5706
;
hsa-mir-4782-5p
;
hsa-mir-516b-5p
;
hsa-mir-488-5p
;
hsa-mir-4778-5p
;
hsa-mir-2355-3p
;
hsa-mir-676-3p
;
hsa-mir-6820-3p
;
hsa-mir-3164
;
hsa-mir-3118
;
hsa-mir-134-5p
;
hsa-mir-3607-5p
;
hsa-mir-3177-5p
;
hsa-mir-4252
;
hsa-mir-20b-3p
;
hsa-mir-3137
;
hsa-mir-449b-3p
;
hsa-mir-892a
Nearest miRNA
hsa-mir-10397/Upstream/478982; hsa-mir-103a-1/Downstream/2542135;
Nearest TSS
ENST00000502646/Upstream/5108;
ENST00000500093/Downstream/6884;
Nearest CpG islands
None/Target,
chr5-CpG: 87/Upstream/165770
,
chr5-CpG: 107/Downstream/6599
Target sequence
GATCACAAGGTCAGGAGTTTGAGACCAGCCTGGCCAATATGGTGAAACGCTGTCTCTACTAAAAATATGAAAATTAGCTGGTCGTGGTGGTGGGCACCTATAGTCCCAGCTACTTGGGAGGCTGAGGCAGAAGAATTGCTCGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGAATGCACCACTGCACTCCAGCCTGGGCGACAGAGTGAGGCTCTGCCTCCAAAAAAAAAAAAAAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Sample Information
×
Sample name
R1
Sample type
PBMC
Gender
Female
CpG Island Information
×
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