Basic Information
VIS ID
TVIS30001267
Fusion event
HIV-LYST integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.3
Reference genome
GRCh37/hg19
Start
235827798/235664498 (Hg38)
End
235828152/235664498 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA1H
Target gene
LYST
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-93-5p ; hsa-mir-92b-3p ; hsa-mir-193a-3p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/474382; hsa-mir-1537/Downstream/188502;
Nearest TSS
ENST00000473358/Upstream/13744; ENST00000412098/Downstream/47902;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/13310, chr1-CpG: 113/Downstream/201789
Target sequence
CATTGATAGATACTCCCTCAGGCTGGTTGGAGAAAGCCACGGAACAGATGATCTCCCTGCAGTGGACATGTCCAACGAGATCCCCGTTCACCGTCCAGAGTCTGAGGTCACTGCCTCCGCCAGCTAAAACACCCAAATCATCCGGCGGGTTACCAGAATGTGGCTGTCTCAGAGCCCACATTTGGCCCCAGAAGGGCAACCCTGAAGGGCAAGCTCATTTGTTTATTGATGAAGTTTGTAGACAACCCATGACTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate