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TVIS30001269
Basic Information
VIS ID
TVIS30001269
Fusion event
HIV-MAPK14 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
36045417/36077640 (Hg38)
End
36046366/36077640 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
MAPK14
miRNAs that regulate target gene
hsa-mir-124-3p
;
hsa-mir-24-3p
;
hsa-mir-199a-3p
;
hsa-mir-200a-3p
;
hsa-mir-141-3p
;
hsa-mir-125b-5p
;
hsa-mir-214-3p
;
hsa-mir-155-5p
;
hsa-mir-17-5p
;
hsa-mir-106a-5p
;
hsa-mir-19a-3p
;
hsa-mir-19b-3p
;
hsa-mir-518a-5p
;
hsa-mir-527
;
hsa-mir-128-3p
;
hsa-mir-3152-5p
;
hsa-mir-4774-3p
;
hsa-mir-6836-3p
;
hsa-mir-585-5p
;
hsa-mir-668-3p
;
hsa-mir-6781-3p
;
hsa-mir-2682-3p
;
hsa-mir-215-3p
;
hsa-mir-3137
;
hsa-mir-6773-3p
;
hsa-mir-1208
;
hsa-mir-6760-3p
;
hsa-mir-1183
;
hsa-mir-548e-5p
;
hsa-mir-6820-3p
;
hsa-mir-3164
;
hsa-mir-6757-3p
;
hsa-mir-4454
;
hsa-mir-4680-5p
;
hsa-mir-7107-5p
;
hsa-mir-1234-3p
;
hsa-mir-186-3p
;
hsa-mir-764
;
hsa-mir-125a-3p
;
hsa-mir-548aw
;
hsa-mir-4719
;
hsa-mir-4762-5p
;
hsa-mir-34b-3p
;
hsa-mir-129-5p
;
hsa-mir-8055
;
hsa-mir-744-3p
;
hsa-mir-6864-3p
;
hsa-mir-3672
;
hsa-mir-6867-3p
;
hsa-mir-664b-3p
;
hsa-mir-579-3p
;
hsa-mir-4423-5p
;
hsa-mir-4294
;
hsa-mir-6501-5p
;
hsa-mir-367-5p
;
hsa-mir-1267
;
hsa-mir-4685-3p
;
hsa-mir-4287
;
hsa-mir-7113-3p
;
hsa-mir-4469
;
hsa-mir-153-5p
;
hsa-mir-1250-3p
;
hsa-mir-335-3p
;
hsa-mir-642a-5p
;
hsa-mir-5696
;
hsa-mir-2276-5p
;
hsa-mir-6892-3p
;
hsa-mir-629-3p
;
hsa-mir-4715-3p
;
hsa-mir-3064-3p
;
hsa-mir-4279
;
hsa-mir-513b-5p
;
hsa-mir-4252
;
hsa-mir-205-5p
;
hsa-mir-181a-2-3p
;
hsa-mir-4482-3p
;
hsa-mir-7159-3p
;
hsa-mir-4775
;
hsa-mir-6831-3p
;
hsa-mir-643
;
hsa-mir-4735-5p
;
hsa-mir-590-3p
;
hsa-mir-27a-3p
;
hsa-mir-125a-5p
;
hsa-mir-4524a-3p
;
hsa-mir-4524b-3p
;
hsa-mir-4712-3p
;
hsa-mir-6759-3p
Nearest miRNA
hsa-mir-1236/Upstream/412851; hsa-mir-10398/Downstream/544796;
Nearest TSS
ENST00000381078/Upstream/1775;
ENST00000476951/Downstream/50169;
Nearest CpG islands
None/Target,
chr6-CpG: 120/Upstream/49045
,
chr6-CpG: 72/Downstream/52622
Target sequence
ATTATGAACTGAAAAAACCTCTATTTCTCAGGTAAAGCTGTTTCTTTCTCTCTGAATATTAGGATTGATAACAGAGTTCAGTCTCCCTGTATTTAGCTTACCTTATTACTCCCTACCTCTGGATTTTAAATTAGTTTAATACCTGGTGTTTCTCCTTTGTCCTTTGTTTCATTCACCTTATATCTGTTTCTCAGAAATTTGGTATATATATATTACAGTCCAAGGTAAGAGAATTAGGGAAAATTCATACTTCCC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Sample Information
×
Sample name
R1
Sample type
PBMC
Gender
Female
CpG Island Information
×
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