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TVIS30001272
Basic Information
VIS ID
TVIS30001272
Fusion event
HIV-NF2 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
30022963/29626974 (Hg38)
End
30023928/29626974 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
NF2
miRNAs that regulate target gene
hsa-let-7a-5p
;
hsa-mir-193b-3p
;
hsa-mir-1229-3p
;
hsa-mir-10a-5p
;
hsa-mir-25-3p
;
hsa-mir-32-5p
;
hsa-mir-92a-3p
;
hsa-mir-363-3p
;
hsa-mir-367-3p
;
hsa-mir-92b-3p
;
hsa-mir-185-3p
;
hsa-mir-423-5p
;
hsa-mir-762
;
hsa-mir-3184-5p
;
hsa-mir-4486
;
hsa-mir-4492
;
hsa-mir-4498
;
hsa-mir-4505
;
hsa-mir-5001-5p
;
hsa-mir-5787
;
hsa-mir-6085
;
hsa-mir-6813-5p
;
hsa-mir-1273e
;
hsa-mir-4497
;
hsa-mir-25-5p
;
hsa-mir-658
;
hsa-mir-4722-5p
;
hsa-mir-1827
;
hsa-mir-6087
;
hsa-mir-219b-3p
;
hsa-mir-4459
;
hsa-mir-4768-3p
;
hsa-mir-940
;
hsa-mir-6893-5p
;
hsa-mir-6808-5p
;
hsa-mir-302f
;
hsa-mir-4668-5p
;
hsa-mir-31-5p
;
hsa-mir-5681a
;
hsa-mir-6779-5p
;
hsa-mir-5589-3p
;
hsa-mir-3922-5p
;
hsa-mir-4312
;
hsa-mir-4696
;
hsa-mir-454-3p
;
hsa-mir-4295
;
hsa-mir-3666
;
hsa-mir-301b-3p
;
hsa-mir-301a-3p
;
hsa-mir-130b-3p
;
hsa-mir-130a-3p
;
hsa-mir-362-3p
;
hsa-mir-329-3p
;
hsa-mir-8485
;
hsa-mir-1273g-3p
;
hsa-mir-7703
;
hsa-mir-6729-5p
;
hsa-mir-4649-5p
;
hsa-mir-1273a
;
hsa-mir-661
;
hsa-mir-3117-5p
;
hsa-mir-4793-3p
;
hsa-mir-766-3p
;
hsa-mir-939-3p
;
hsa-mir-6849-3p
;
hsa-mir-508-5p
;
hsa-mir-1228-5p
;
hsa-mir-1253
;
hsa-mir-125a-5p
;
hsa-mir-125b-5p
;
hsa-mir-1285-3p
;
hsa-mir-3187-5p
;
hsa-mir-326
;
hsa-mir-330-5p
;
hsa-mir-345-3p
;
hsa-mir-378g
;
hsa-mir-4319
;
hsa-mir-4488
;
hsa-mir-4732-3p
;
hsa-mir-5189-5p
;
hsa-mir-612
;
hsa-mir-670-5p
;
hsa-mir-6770-5p
;
hsa-mir-6860
;
hsa-mir-7113-3p
;
hsa-mir-1207-5p
;
hsa-mir-1471
;
hsa-mir-3148
;
hsa-mir-3917
;
hsa-mir-4281
;
hsa-mir-4434
;
hsa-mir-4449
;
hsa-mir-4516
;
hsa-mir-4690-5p
;
hsa-mir-4736
;
hsa-mir-4746-5p
;
hsa-mir-4763-3p
;
hsa-mir-4783-3p
;
hsa-mir-4795-5p
;
hsa-mir-542-3p
;
hsa-mir-5703
;
hsa-mir-6165
;
hsa-mir-6510-5p
;
hsa-mir-7150
Nearest miRNA
hsa-mir-1286/Upstream/1167026; hsa-let-7a-3/Downstream/380075;
Nearest TSS
ENST00000624155/Upstream/22975;
ENST00000216144/Downstream/92740;
Nearest CpG islands
None/Target,
chr22-CpG: 279/Upstream/22810
,
chr22-CpG: 131/Downstream/93167
Nearest cancer related gene
NF2
(TSG, No orient, 0)
Target sequence
GGCCTTAAGGTATATATTTTACCCCTTTGGTGAAACATACTGATTTCCTCTCTCTAAAAATACCTTGGCAAGGAAATCTAAATCTCAAACAACCAAAGAAGAAAATTTTCCACAGAACAAAGGAGACTAGTAAGAAACAAATCACAGCACCTTGGGAAGCCACAAAATGGAGCTTTTAAACTCTGGTAAGTCTTTCAAAACCAAATGAATTACAGTTTTTTAGGGGAAAAAAAGGCCTTATGCTTGCAGTTTCTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Sample Information
×
Sample name
R1
Sample type
PBMC
Gender
Female
CpG Island Information
×
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