VISDB - VIS Detail

Basic Information

VIS ID

TVIS30001273

Fusion event

HIV-NFATC2IP integration

Validated

Yes

Detection method

QiaQuick PCR and Sequencing

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

25011556

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr16

Cytoband

p11.2

Reference genome

GRCh37/hg19

Start

28970893/28959572 (Hg38)

End

28971511/28959572 (Hg38)

Orient

Location type

Intronic

Target gene

NFATC2IP

miRNAs that regulate target gene

hsa-mir-122-5p ; hsa-mir-155-5p ; hsa-mir-760 ; hsa-mir-92b-3p ; hsa-mir-193b-3p ; hsa-mir-20b-5p ; hsa-mir-31-5p ; hsa-let-7a-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-16-2-3p ; hsa-mir-195-3p ; hsa-mir-3662 ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-142-3p ; hsa-mir-3671 ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-371a-5p ; hsa-mir-372-5p ; hsa-mir-373-5p ; hsa-mir-519d-3p ; hsa-mir-616-5p ; hsa-mir-3653-5p ; hsa-mir-371b-5p ; hsa-mir-6778-3p ; hsa-mir-3674 ; hsa-mir-744-3p ; hsa-mir-4474-5p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-4732-5p ; hsa-mir-6832-5p ; hsa-mir-8086 ; hsa-mir-4781-3p ; hsa-mir-129-5p ; hsa-mir-374b-3p ; hsa-mir-4766-3p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-1976 ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-4722-3p ; hsa-mir-2861 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-661 ; hsa-mir-939-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-512-3p ; hsa-mir-5587-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-323a-5p ; hsa-mir-6801-5p ; hsa-mir-4483 ; hsa-mir-1293 ; hsa-mir-4680-5p ; hsa-mir-4635 ; hsa-mir-6823-5p ; hsa-mir-3658 ; hsa-mir-6758-3p ; hsa-mir-7856-5p

Nearest miRNA

hsa-mir-1225/Upstream/911; hsa-mir-11401/Downstream/639607;

Nearest TSS

ENST00000527434/Upstream/1182; ENST00000567771/Downstream/7311;

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/8102, chr16-CpG: 78/Downstream/14988

Target sequence

GTTAGAGTGGGGCTAGCCCAACATGACCTATGTCTTTCCAAGAAGAGAGACGAACACAGACAGAGACACATGGAGAACACCGTGTGATCACAGAGGGAGAGACTGGAGTGACACAGCTGCAAGCCAAGGAACTCTGGCCACCAGCAGAAGCTAGAAAGAGGTAAGGAAGGTTTCCACTCAGATTCTCAGACGGAACCAGGCCCTGCCAACACCTTCAATTCAGACTTCTAGGCTCCAGAAGTGTACAGGAATAGG

Reference

Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.