VISDB - VIS Detail

Basic Information

VIS ID

TVIS30001277

Fusion event

HIV-POC1A integration

Validated

Yes

Detection method

QiaQuick PCR and Sequencing

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

25011556

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr3

Cytoband

p21.2

Reference genome

GRCh37/hg19

Start

52141609/52107593 (Hg38)

End

52142544/52107593 (Hg38)

Orient

Location type

Intronic

Target gene

POC1A

miRNAs that regulate target gene

hsa-mir-7111-5p ; hsa-mir-4694-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-6825-5p ; hsa-mir-7106-5p ; hsa-mir-1193 ; hsa-mir-6894-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-4468 ; hsa-mir-3605-5p ; hsa-mir-4725-5p ; hsa-mir-196b-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-148a-3p ; hsa-mir-6798-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-2392 ; hsa-mir-2278 ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-498 ; hsa-mir-6869-5p ; hsa-mir-4303 ; hsa-mir-4279 ; hsa-mir-4682 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-1237-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-3614-3p ; hsa-mir-5571-5p ; hsa-mir-7641 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-4284 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-4695-3p ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-1281 ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-660-3p ; hsa-mir-4485-5p ; hsa-mir-6890-3p ; hsa-mir-5089-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-6504-3p ; hsa-mir-7108-5p ; hsa-mir-663b ; hsa-mir-874-5p ; hsa-mir-1228-3p

Nearest miRNA

hsa-mir-12127/Upstream/1432430; hsa-let-7g/Downstream/160685;

Nearest TSS

ENST00000440867/Upstream/51043; ENST00000459884/Downstream/46811;

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/49957, chr3-CpG: 74/Downstream/46662

Target sequence

CCTACCCAATACCTGGAGACAAAAATGCCTACCCTCCCACAGCACATACCTGAACCGAGGTACCCTGGTAGGGAGATCAAGGATTCCGATAAAGCCCAAGTGCTGACTGTAGATTTCTTTTATATTAAACTGCTTTGAACTAATTTTAGAATTGGAGAAAAGTTGCAAAAAATAGTACAGAGAATTTCCATATATCCCTCTGCCAGTGTTAATGTCTTACACAACCATAGGACAATGATCAGACCAGGAAACTAA

Reference

Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.