Basic Information
VIS ID
TVIS30001279
Fusion event
HIV-PSEN1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
73611010/73144302 (Hg38)
End
73611466/73144302 (Hg38)
Orient
-
Location type
Intronic
Target gene
PSEN1
miRNAs that regulate target gene
hsa-mir-562 ; hsa-mir-155-5p ; hsa-mir-183-5p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-935 ; hsa-mir-5000-5p
Nearest miRNA
hsa-mir-208a/Upstream/627404; hsa-mir-1185-1/Downstream/614445;
Nearest TSS
ENST00000550708/Upstream/7485; ENST00000556066/Downstream/3190;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/7263, chr14-CpG: 119/Downstream/93044
Target sequence
ATTATTCACTAAACAAGAAAGACACTGTCTACTTATATGTAAAACTTAGAGACATTATTAAACTAAGGCTTAACAAACTAATTTATGATATTCCCTTTATCCTTTTACAGATGAAAACAGTGTGGCACACAGAAGTTCACTTGCTTAAGGTCACATCTGGCAAGTGAGGAGTTGGAATTCACAGAGTACACTATATTGCCTCTTTATAAAACTCCAAACCTGCCCCGTAGGAGTTTACAGCAATGAGGATTACGG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate