Basic Information
VIS ID
TVIS30001280
Fusion event
HIV-RABEP1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
5238351/5335056 (Hg38)
End
5239259/5335056 (Hg38)
Orient
-
Location type
Intronic
Target gene
RABEP1
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-let-7f-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-552-3p ; hsa-mir-551b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1253/Upstream/364906; hsa-mir-10226/Downstream/1320384;
Nearest TSS
ENST00000595228/Upstream/3001; ENST00000574568/Downstream/19345;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/52209, chr17-CpG: 95/Downstream/84131
Target sequence
GATACCGAGAAAGAAGGAAAACTAACATCTATTCTAAAACTTTGCTTTAGACACAATCATCAAGCAACAACACCCGCTCAACTGGTATTTAGGAGTTCAAGCACCTATCTCCTAGACACTATGCTAGGCATTTAGGATATACAAATAAAAAACAAGCACATGTACCCCTGAAGCTATTAAAAAAAAAGAGAGAAAGAGAAACTCCTGCCTTCACAGAGCTTATATTTTAGCAAGGAAAGAAAGACAGTAAACAAT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate