VISDB - VIS Detail

Basic Information

VIS ID

TVIS30001282

Fusion event

HIV-SEC16A integration

Validated

Yes

Detection method

QiaQuick PCR and Sequencing

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

25011556

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr9

Cytoband

q34.3

Reference genome

GRCh37/hg19

Start

139355926/136461474 (Hg38)

End

139356406/136461474 (Hg38)

Orient

Location type

Intronic

Target gene

SEC16A

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-let-7b-5p ; hsa-mir-877-5p ; hsa-mir-744-5p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-27b-3p ; hsa-mir-93-5p ; hsa-mir-27a-3p ; hsa-mir-218-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-1228-5p ; hsa-mir-1249-5p ; hsa-mir-128-3p ; hsa-mir-130a-3p ; hsa-mir-130b-3p ; hsa-mir-1321 ; hsa-mir-216a-3p ; hsa-mir-22-5p ; hsa-mir-301a-3p ; hsa-mir-301b-3p ; hsa-mir-3127-5p ; hsa-mir-3150b-3p ; hsa-mir-3175 ; hsa-mir-3612 ; hsa-mir-3666 ; hsa-mir-3681-3p ; hsa-mir-3691-3p ; hsa-mir-3918 ; hsa-mir-4295 ; hsa-mir-4302 ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-454-3p ; hsa-mir-4689 ; hsa-mir-4710 ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-4773 ; hsa-mir-4779 ; hsa-mir-4784 ; hsa-mir-503-5p ; hsa-mir-5088-5p ; hsa-mir-519a-3p ; hsa-mir-519b-3p ; hsa-mir-519c-3p ; hsa-mir-542-5p ; hsa-mir-5582-5p ; hsa-mir-5695 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-648 ; hsa-mir-650 ; hsa-mir-6727-5p ; hsa-mir-6777-5p ; hsa-mir-6797-5p ; hsa-mir-6858-5p ; hsa-mir-6878-5p ; hsa-mir-6889-5p

Nearest miRNA

hsa-let-7a-1/Upstream/1610667; hsa-mir-126/Downstream/58094;

Nearest TSS

ENST00000422679/Upstream/12632; ENST00000354376/Downstream/1487;

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/6121, chr9-CpG: 40/Downstream/4757

Target sequence

GGTATTTGTAGATATTTGCTGCTTTTATCCATTTTCAGCATAAAACACAAGCACGCTAATCACAAACAGGGCTAACCACGCAGCGCTGCCCACCACGCCGCCCCATCCACTGGGAAACACGCTCGAGTCAACTCCCCAGTTCTAACAGGAGGCCTCCGCGAATATCCTGTCAACACGGAGAGTGACTCCCGTAAGGCAGCCTCCCCTTTCACCAAAATCATCCAGGGCATAATTTAGAACTTCTGGCTGGGAGGC

Reference

Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.