Basic Information
VIS ID
TVIS30001283
Fusion event
HIV-SNX8 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
2335506/2295871 (Hg38)
End
2336299/2295871 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
SNX8
miRNAs that regulate target gene
hsa-mir-423-5p ; hsa-mir-107 ; hsa-mir-4774-3p ; hsa-mir-24-2-5p ; hsa-mir-4312 ; hsa-mir-24-1-5p ; hsa-mir-518c-5p ; hsa-mir-1915-5p ; hsa-mir-3664-5p ; hsa-mir-514a-5p ; hsa-mir-4714-5p
Nearest miRNA
hsa-mir-339/Upstream/38294; hsa-mir-10399/Downstream/231203;
Nearest TSS
ENST00000635602/Upstream/23975; ENST00000413917/Downstream/3566;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/16427, chr7-CpG: 91/Downstream/18123
Target sequence
GCCACCACACCCGGCTGTTTCAAAATATCTTAATGTTACATCACATTAAATAAGGTATTAAATAGCCCCATTTATATAGCAATCAGGCAAGAGAAATAAAGTGCATCTGGATTGGAAGAGAGGAAGTCAAACTATCTCTGTTTGCTGATGATATGATATTATACCTAGAACACCCTCAAGACTCCTCTAGAAGACTCCTAGATTTGAGAAAAGAATTCAGTGAAGTTTCAGGTTACAAAATCAGTATACACAAAT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate