Basic Information
VIS ID
TVIS30001284
Fusion event
HIV-ST13 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
41248185/40852181 (Hg38)
End
41249128/40852181 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
ST13
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-183-5p ; hsa-let-7b-5p ; hsa-mir-19b-3p ; hsa-mir-4677-5p ; hsa-mir-526b-5p ; hsa-mir-22-5p ; hsa-mir-2116-5p ; hsa-mir-4480 ; hsa-mir-4424 ; hsa-mir-26b-3p ; hsa-mir-4633-5p ; hsa-mir-3149 ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-6069 ; hsa-mir-661 ; hsa-mir-3116 ; hsa-mir-1254 ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-6872-3p ; hsa-mir-3591-3p ; hsa-mir-21-3p
Nearest miRNA
hsa-mir-1286/Upstream/38223; hsa-let-7a-3/Downstream/240332;
Nearest TSS
ENST00000624155/Upstream/7291; ENST00000614001/Downstream/2417;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/32609, chr22-CpG: 88/Downstream/3961
Nearest cancer related gene
ST13(TSG, No orient, 0)
Target sequence
ATCAGCAATGTATGAGAATTCCAATTGTTTCACGCCTTGGCCAATGCTTAGCTATTGTCCATCTTAAAGATTTTTTAGCCATTCTGATAGGTGCCTACTGGCATCTCATTGCAGTTGAGTCCCTTTTCATATATTTACTGGTCATTTAAAAAGACTTTTTTGTACAGTTCAACTCTCATCCAGCTTTCTAATAGATTGTCCTTCTTTATTTGAAGGTGTTGTCTGTATTCTGCATATGAACCCTTTGTCAGCTTT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate