Basic Information
VIS ID
TVIS30001287
Fusion event
HIV-USP24 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
55587108/55121435 (Hg38)
End
55587902/55121435 (Hg38)
Orient
+
Location type
splicing
Fragile sites / regions
FRA1B
Target gene
USP24
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-let-7d-5p ; hsa-mir-1226-3p ; hsa-mir-935 ; hsa-mir-193b-3p ; hsa-mir-181b-5p
Nearest miRNA
hsa-mir-12136/Upstream/1067281; hsa-mir-101-1/Downstream/104206;
Nearest TSS
ENST00000473358/Upstream/26116; ENST00000451250/Downstream/32482;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/81093, chr1-CpG: 133/Downstream/93357
Target sequence
CTCAGCACTTGGTGATCCGAGCAGAATATCAATGATGAAATCAGCAACACAGGGCAAGTTATAGAAAGATGCTAATAAGAAGAAATGGGGGATGTGGGTGTGTGAAACAAGTTAGGTAATGCATTTTCAAATTTTGATTAATTTCTTAAGCTCAACTTAAGCATAAGCTCTTCTCTTTTACATACAATAATTCAGGACCTTTTACAATTGCTTTCATGCCTGTCCATTTACCCCATAAAATTCTAAGTTGTTCAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate