Basic Information
VIS ID
TVIS30001299
Fusion event
HIV-chr11 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
88003624/88270456 (Hg38)
End
88004318/88270456 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA11F
Nearest miRNA
hsa-mir-10392/Upstream/93863; hsa-let-7a-2/Downstream/2285318;
Nearest TSS
ENST00000527297/Upstream/94989; ENST00000531994/Downstream/29299;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/94838, chr11-CpG: 49/Downstream/66877
Nearby gene
CTSC(No orient, 23136)
Target sequence
AAAATAAACAAATCTTTAGCCAGACTAAGAAAAAAGGAAAGAAGACCAAAATAAATAAAATCTTGAATAAGGAGACATTACAATCGCTACAGCAGAAATTCACAGGATTAATAGACTACTATAAGTGGCTATATGCAATAAATTAGAAAATCTGGATGAAATGTAGATACATACCCCCTGCCAAGATTGAACTGTGAAGAAATCCAAAACCTGAACAGACCAATAAAAAGTAATCAGATTGAAGCTGTAATGAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate