Basic Information
VIS ID
TVIS30001306
Fusion event
HIV-ZBTB21 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
43410654/41990545 (Hg38)
End
43411591/41990545 (Hg38)
Orient
+
Location type
UTR3
Target gene
ZBTB21
miRNAs that regulate target gene
hsa-mir-548b-3p ; hsa-mir-186-5p ; hsa-mir-140-3p ; hsa-mir-101-3p ; hsa-mir-93-5p ; hsa-mir-425-5p ; hsa-mir-30e-5p ; hsa-mir-6507-5p ; hsa-mir-3119 ; hsa-mir-510-3p ; hsa-mir-488-3p ; hsa-mir-875-5p ; hsa-mir-4715-5p ; hsa-mir-4282 ; hsa-mir-6875-3p ; hsa-mir-2053 ; hsa-mir-569 ; hsa-mir-4772-5p ; hsa-mir-383-5p ; hsa-mir-6845-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-3919 ; hsa-mir-4756-3p ; hsa-mir-3620-3p ; hsa-mir-6865-3p
Nearest miRNA
hsa-let-7c/Upstream/243704; hsa-mir-5692b/Downstream/960383;
Nearest TSS
ENST00000624081/Upstream/36655; ENST00000412906/Downstream/17512;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/36265, chr21-CpG: 233/Downstream/18625
Target sequence
GACAGTATTCCACTAATCAATAAAAAACCAAAAACCTCAATTAAATGATTATACTGACACCATGGAATGAGGAACCATGCACACAATCAAGACTAATCCAATTTCAACATTAATGAAATCAAACCATCTTGTTCTTGTAAGGTCCAGAACCACAATATTTTAAAAGCTGTATTTCTAAAGTTAAGGACATTACTAAGTAATTATCAATTTGCCTCCAACTTAATTTCAAGCGTAACAATCTCCAACCTTTATTAT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate