Basic Information
VIS ID
TVIS30001308
Fusion event
HIV-ZCCHC7 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
37295685/37295688 (Hg38)
End
37296112/37295688 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZCCHC7
miRNAs that regulate target gene
hsa-mir-365a-3p
Nearest miRNA
hsa-mir-101-2/Upstream/402157; hsa-let-7a-1/Downstream/3633322;
Nearest TSS
ENST00000422679/Upstream/11525; ENST00000497924/Downstream/30346;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/174700, chr9-CpG: 44/Downstream/126883
Target sequence
GGAAGGAAAGTAGGGGTTTTGTTTTTGTATCTTTAAGGAAGAGAAAATAATTCCATTTTAGTGAATATGAGTTTGAAATACCTGTGAGACATCCAAGAAAAGACATGGCTAGAGAAGCAAATTTGGTAGTTCTCACTATGGGCATATATGACATAATCTGGGAGAAAAGTTGTAGAAGAAAATGGGTAAAGTATGGAGTATACCAAGTAACTAGTGAAGAGGAAACCACAAAGGGGGACAAGAGATAGGAAAGCA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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