Basic Information
VIS ID
TVIS30001315
Fusion event
HIV-AATF integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
35337140/36979841 (Hg38)
End
35337464/36979841 (Hg38)
Orient
-
Location type
Intronic
Target gene
AATF
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-151a-3p ; hsa-mir-149-5p ; hsa-let-7b-5p ; hsa-mir-4530 ; hsa-mir-1226-3p ; hsa-mir-634 ; hsa-mir-525-3p ; hsa-mir-524-3p
Nearest miRNA
hsa-mir-1180/Upstream/4629639; hsa-mir-10226/Downstream/53904;
Nearest TSS
ENST00000595228/Upstream/30822; ENST00000610798/Downstream/8817;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/30384, chr17-CpG: 76/Downstream/379012
Target sequence
GAGTCTCAATTTTCTCGTTTATAAAATGTGGACAAGCCTTTGCTTGTCCTTACAAAATAAGGTAAAAATAGTAACTGTGTTATTATATATTAAGGCATTTTAGAATTTTTTTAATGCTGTAAAAATAGAAGGCATATTACTATCAAAAATCATATTTCACATGGTAAAAATCTTAAGCTCTGCTTGTACTAGGATTGGACAGTATTCACAGACTCCTATATTAGGTATTCATTTATATGCTACCCATATGCAAGC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate