Basic Information
VIS ID
TVIS30001318
Fusion event
HIV-CBL integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
119143702/119272992 (Hg38)
End
119144459/119272992 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
CBL
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-let-7c-5p ; hsa-mir-150-5p ; hsa-mir-155-5p ; hsa-mir-98-5p ; hsa-mir-188-3p ; hsa-mir-218-5p ; hsa-mir-1273d ; hsa-mir-7973 ; hsa-mir-6846-3p ; hsa-mir-6859-3p ; hsa-mir-4287 ; hsa-mir-4685-3p ; hsa-mir-1224-3p ; hsa-mir-1306-5p ; hsa-mir-216a-5p ; hsa-mir-124-3p ; hsa-mir-1972 ; hsa-mir-3150b-3p ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-4693-3p ; hsa-mir-4717-5p ; hsa-mir-4784 ; hsa-mir-5192 ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-10392/Upstream/362205; hsa-let-7a-2/Downstream/39958;
Nearest TSS
ENST00000527297/Upstream/66568; ENST00000634301/Downstream/25380;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/66148, chr11-CpG: 19/Downstream/37694
Nearest cancer related gene
CBL(TSG, No orient, 0)
Target sequence
GTAATTCAAAATACAGGTCAACTTCTTTAAGAAAAGAAAGAAGGGGACCAGGAGCCACGGTGCATGCCTTTGGGAGGCCCAGCACTTTGAGAGGCCAAAGTGGGCAGACTGCTTGAGCCCAGACTGGGCAATATGGTGAAACTTTGTCTCTACAAAAACAAACAAACAAACAAAATTAGCCAGACTAATTAGTTCCAGCTACTCTGGAGGCTGAGGTGGGAAAATCACTTGAACTTTGGAGGCAGAGGTTGCAAG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate