Basic Information
VIS ID
TVIS30001320
Fusion event
HIV-CBLB integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
105382795/105663951 (Hg38)
End
105382941/105663951 (Hg38)
Orient
-
Location type
Intronic
Target gene
CBLB
miRNAs that regulate target gene
hsa-mir-6885-3p ; hsa-mir-7162-5p ; hsa-mir-3977 ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-2115-5p ; hsa-mir-4762-5p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-765 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-4635 ; hsa-mir-942-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-151b ; hsa-mir-151a-5p ; hsa-mir-891b
Nearest miRNA
hsa-let-7g/Upstream/2139835; hsa-mir-12124/Downstream/3938877;
Nearest TSS
ENST00000440867/Upstream/113731; ENST00000473550/Downstream/10042;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/294456, chr3-CpG: 84/Downstream/204484
Nearest cancer related gene
CBLB(OG, No orient, 0)
Target sequence
AAAACCCAACCCAATCTTTAGATGATGAGGGGAGTAATAAAGACTTTTTGTGGCAAAATAATTGACAGCCACTGAAATGAAATATCCTCAGTTCTTTAAATGGAGGTTATGTAGATATACAGCAGTGCGTCTCACTTAAAAAAAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate