Basic Information
VIS ID
TVIS30001322
Fusion event
HIV-DCAF13 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
104448893/103436665 (Hg38)
End
104449645/103436665 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8A
Target gene
DCAF13
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-149-5p
Nearest miRNA
hsa-mir-12123/Upstream/281976; hsa-mir-10400/Downstream/1047704;
Nearest TSS
ENST00000518652/Upstream/21253; ENST00000611541/Downstream/2817;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/21070, chr8-CpG: 243/Downstream/62162
Target sequence
GTTTTCACTTTACAGACTGACTTTAAAAACTAAGTCCTGTATAGATACAGCCCCCTGTATAGTGAATTATGGTTTACAAAGAGCTGTTATACACATTCCCATTGTTCCTTAGTAATGCTTTAGATGTGTTCCTGGAAGCATCCATAAAATAAATCCAAATAAATGGAAATAATTTTTCTCAAAAAATTATGATAATTGGATGATCATGGTCATAGTCAATCTGCTTATCTAACTCTTTGCTCTTTTACTTGTGAT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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