Basic Information
VIS ID
TVIS30001325
Fusion event
HIV-EIF4G3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
21202989/20876496 (Hg38)
End
21203414/20876496 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
EIF4G3
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-24-3p ; hsa-mir-16-5p ; hsa-mir-221-3p ; hsa-mir-17-5p ; hsa-mir-3613-3p ; hsa-mir-543 ; hsa-mir-136-5p ; hsa-mir-377-5p ; hsa-mir-218-5p ; hsa-mir-548c-3p ; hsa-mir-4724-3p ; hsa-mir-6813-3p ; hsa-mir-3200-3p
Nearest miRNA
hsa-mir-12136/Upstream/242708; hsa-mir-101-1/Downstream/111818;
Nearest TSS
ENST00000473358/Upstream/28551; ENST00000416959/Downstream/64902;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/88868, chr1-CpG: 77/Downstream/300126
Target sequence
AAACCAAAAAAACCTCTTTATACATACTCATATTTTCATGTGATTTTATAAACATGAAGAAAACTATAGATGATTACATCAAAACCATTCACAGTGACCATCTGATAGGGAAGGAAGATTAACTGGCTGGGGCTGCAAGCAGAGAGTAATAACTGTATTAACTATACCATTTGACTTGTTCAAATAGGTTGTTATCTTATAATTTAAAATAATCCAGGAGGCCAGGAGGTGTCTCCTGCCTGTAATCCCTGCACT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate