Basic Information
VIS ID
TVIS30001326
Fusion event
HIV-FAM168A integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
73275791/73564746 (Hg38)
End
73275870/73564746 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
FAM168A
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-10a-5p ; hsa-mir-8081 ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-555 ; hsa-mir-765 ; hsa-mir-5702 ; hsa-mir-6861-5p ; hsa-mir-6742-3p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-331-3p ; hsa-mir-3139 ; hsa-mir-708-5p ; hsa-mir-28-5p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-6801-5p ; hsa-mir-4266 ; hsa-mir-766-5p ; hsa-mir-3202 ; hsa-mir-3179 ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-450a-2-3p ; hsa-mir-6857-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6810-5p ; hsa-mir-2110 ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-4722-5p ; hsa-mir-6731-5p ; hsa-mir-1827 ; hsa-mir-4768-3p ; hsa-mir-4259 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6888-5p ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-10392/Upstream/781154; hsa-let-7a-2/Downstream/834491;
Nearest TSS
ENST00000527297/Upstream/96254; ENST00000536527/Downstream/33351;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/187509, chr11-CpG: 63/Downstream/33008
Target sequence
GGCACTTACCACATTGTTCTGCAATTATGTTTCTTTTAGACTAGAGCTATACCTCTAGCCTTCTTTTTTTTTTTTTTTT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate