Basic Information
VIS ID
TVIS30001327
Fusion event
HIV-FEZ2 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
36805105/36577962 (Hg38)
End
36806036/36577962 (Hg38)
Orient
+
Location type
Intronic
Target gene
FEZ2
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-155-5p ; hsa-mir-943 ; hsa-mir-4439 ; hsa-mir-4477a ; hsa-mir-3136-5p ; hsa-mir-3682-5p ; hsa-mir-302a-5p ; hsa-mir-634 ; hsa-mir-4282
Nearest miRNA
hsa-mir-1301/Upstream/1106476; hsa-mir-10b/Downstream/10799713;
Nearest TSS
ENST00000437798/Upstream/16464; ENST00000457137/Downstream/870;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/220123, chr2-CpG: 56/Downstream/19687
Target sequence
GGAATACACAAGACTTCAACACAAAAAAATCTTATCAAAGGGTCAGCGTTTCAGATGTTCTAAACTTGTTTTCACCAGTCAGAAATAGTCTAGTCTGCCAAATACTAGGCCACATGGCTGATGTCACTTACCTTCTTGTATTCCAACCTCACTGAAAAATCAGGAGGAACCTGTTTACAAACAATTTGTGCCTTGAGCAGAGTTCTGATACCTCTAAATAAACCCCTTCTAATTTCTTATCACACAACTCGTAAG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate