Basic Information
VIS ID
TVIS30001330
Fusion event
HIV-HSF1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
145531475/144307789 (Hg38)
End
145531974/144307789 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
HSF1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-let-7c-5p
Nearest miRNA
hsa-mir-1204/Upstream/45052; hsa-mir-10400/Downstream/9457;
Nearest TSS
ENST00000518652/Upstream/15209; ENST00000529630/Downstream/1245;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/15512, chr8-CpG: 158/Downstream/18532
Target sequence
GCATCCCTGTTGGCCGTGGCCGCGGTGGCTCAGAGGGGACATCGAAGGCTTAGGGGACAGCGAGAAGCCCACACGGCGGGGAAGGGGGGCCTGAAGCAGGGCCAGAGAGAGGTGAGGGGTGTCTGCATAGGAAGGGGCGGCTGACTCAGTGAAGAAACTGGTGAAGGGCAGTGGGGCAGGTTTCTCCCTGCCAGGGAAGGGAGCTGCAGATGCAAACAGGGAAAAAGCCAGAAAGACCCCCGTGGTGTGGCACTA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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