Basic Information
VIS ID
TVIS30001332
Fusion event
HIV-INPP4B integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
143095793/142174640 (Hg38)
End
143096408/142174640 (Hg38)
Orient
-
Location type
Intronic
Target gene
INPP4B
miRNAs that regulate target gene
hsa-mir-222-3p ; hsa-mir-181a-5p ; hsa-mir-765
Nearest miRNA
hsa-mir-12113/Upstream/16667333; hsa-mir-1305/Downstream/1168820;
Nearest TSS
ENST00000502981/Upstream/452858; ENST00000514766/Downstream/131192;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/537470, chr4-CpG: 111/Downstream/671147
Nearest cancer related gene
INPP4B(TSG, No orient, 0)
Target sequence
GGTTTCAAGATGAGGAATAAAATTATGGAATTTAAATAATTGAGCTGATAAAAATGTAGTAGACATATTCAGTAAATAACATCGACTGCAAAGTTTTTTGAAAAAATGTCTTGACATTTGGGTATAATGGGATGTAAGCAAGTTTACATGAATCTTGTGCATGCATGAGCCATTACTTCCCTCTTCTTTCCTTCTGGCAACTGTTTTGCTGTTTTGCAGCTTTCCTGCTGGAATGCCTCTTCCTGATGAAATGGA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate