Basic Information
VIS ID
TVIS30001333
Fusion event
HIV-IP6K2 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
48733504/48696071 (Hg38)
End
48734299/48696071 (Hg38)
Orient
+
Location type
Intronic
Target gene
IP6K2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-98-5p ; hsa-mir-125a-3p ; hsa-mir-18a-3p ; hsa-mir-6749-3p ; hsa-mir-3679-3p ; hsa-mir-150-5p ; hsa-mir-361-3p ; hsa-mir-186-3p ; hsa-mir-1264 ; hsa-mir-4668-3p
Nearest miRNA
hsa-mir-12127/Upstream/51791; hsa-let-7g/Downstream/324077;
Nearest TSS
ENST00000440867/Upstream/483; ENST00000435419/Downstream/19346;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/9747, chr3-CpG: 29/Downstream/21073
Target sequence
GACGGGGTTTCACCACGTTGGCTGGCATGGTCTTGATCTCTTGACCTCATGATCTGCCCATTCGGTCTCCCAAAGTGCTGGGATTACAGGTGTGAGCGACCGCACCCAGCCCCATTAATTATATTTTTATAAAATGCATTTAAATACAGGGAAAACCTGCTTACTCATTATCTAGTAAGACTCATTATTTACTTGTCCAGGTTGTCTACCCACACTGCTCCTGCCCAAGGCCAAAGACGAGCCCCATTAACCTTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate