Basic Information
VIS ID
TVIS30001335
Fusion event
HIV-MCCC1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q27.1
Reference genome
GRCh37/hg19
Start
182775803/183058015 (Hg38)
End
182776285/183058015 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3C
Target gene
MCCC1
Nearest miRNA
hsa-let-7g/Upstream/6542864; hsa-mir-1224/Downstream/828785;
Nearest TSS
ENST00000440867/Upstream/20660; ENST00000477699/Downstream/36592;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/77072, chr3-CpG: 40/Downstream/6371
Target sequence
AATAAATAAATATTTTTAAAAGACAGAAAATAGAGACTAAAGTAGGGATACGTAACAAAAAGTACAAACTGTCAAAGAAAAGACTGACAAATTTGACTACATCAAAATTACAAATTATAGTCACTTCCTATATTGTCAAAAGACCAATGAAAAATTTTTTATGACTTTTTGTTTTTAAGCAACTCTTACAGTTAGATTTTATGAATATAGAAGACTGAAATTAAAATGGCTCATCCAGAAAAGTTAAATGTATTA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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