Basic Information
VIS ID
TVIS30001338
Fusion event
HIV-NFATC3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
68133692/68099789 (Hg38)
End
68134480/68099789 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
NFATC3
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-361-3p ; hsa-mir-324-3p ; hsa-let-7b-5p ; hsa-mir-548l ; hsa-mir-548n ; hsa-mir-185-5p ; hsa-mir-7975 ; hsa-mir-320a ; hsa-mir-218-5p ; hsa-mir-3163 ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548e-5p ; hsa-mir-30a-3p ; hsa-mir-103a-2-5p ; hsa-mir-202-5p ; hsa-mir-3154 ; hsa-mir-337-3p ; hsa-mir-3977 ; hsa-mir-4777-5p ; hsa-mir-493-3p ; hsa-mir-518d-5p ; hsa-mir-518e-5p ; hsa-mir-518f-5p ; hsa-mir-519a-5p ; hsa-mir-519b-5p ; hsa-mir-519c-5p ; hsa-mir-520c-5p ; hsa-mir-522-5p ; hsa-mir-523-5p ; hsa-mir-526a ; hsa-mir-6508-5p ; hsa-mir-6885-3p ; hsa-mir-8067 ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-1225/Upstream/897394; hsa-mir-11401/Downstream/133637;
Nearest TSS
ENST00000527434/Upstream/11088; ENST00000565750/Downstream/23241;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/13706, chr16-CpG: 253/Downstream/135318
Target sequence
TACACTATGGGACTTTTTTGGGGGAGGGCAGGGCAGGGGGACAGGGTCTCACTAGGTTGCCAAGGCTGGAGTACAGTGGCATGATTATGCCTCACTGCAGCCTTGAACTCTTGGGCTCAAGCTCTCCTCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCAGGCCCTATGTGACCATTTGAGGTTGACTTTTTCTTCACTCATTGCCTGGCGATCCTTCCAAGTTGTCGAGTATAT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate