Basic Information
VIS ID
TVIS30001339
Fusion event
HIV-NUMA1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
71770031/72058985 (Hg38)
End
71770747/72058985 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
NUMA1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1208 ; hsa-mir-1252-5p ; hsa-mir-1911-3p ; hsa-mir-1972 ; hsa-mir-211-3p ; hsa-mir-4466 ; hsa-mir-4767 ; hsa-mir-6721-5p ; hsa-mir-6753-5p ; hsa-mir-675-5p ; hsa-mir-6760-3p ; hsa-mir-6816-3p ; hsa-mir-7112-3p ; hsa-mir-7112-5p ; hsa-mir-7113-5p
Nearest miRNA
hsa-mir-10392/Upstream/585417; hsa-let-7a-2/Downstream/13243;
Nearest TSS
ENST00000527297/Upstream/16843; ENST00000537483/Downstream/11078;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/245178, chr11-CpG: 51/Downstream/21354
Target sequence
TTATCAATACAGCATTCTTTGACATGCAAAACACTGTGAACAACCTAAATGTCCAGATGTAGCAAAATGGGAAAATAAAGTTGTGGCACATTCTTACATAGGATTTTTTTAAGCTTTTAAAAGTTTAAGGAATTGCCAGCCATGACAGCTCACACCTGTAATCCCAGCACTTTGGGAGGACAAGGTGGGCGGATTGTTTGAGCCTAGGAGTTTGAGAACAGTTTGGGCAACATGGTGAAATCCCATCTCTACAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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