Basic Information
VIS ID
TVIS30001341
Fusion event
HIV-NUP88 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
5305309/5401989 (Hg38)
End
5305651/5401989 (Hg38)
Orient
+
Location type
Intronic
Target gene
NUP88
Nearest miRNA
hsa-mir-1253/Upstream/431839; hsa-mir-10226/Downstream/1253451;
Nearest TSS
ENST00000595228/Upstream/2356; ENST00000575711/Downstream/16240;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/119142, chr17-CpG: 95/Downstream/17198
Target sequence
GTTTCACATATGAAAATGTTACTCTCATTAGAAGAACCAAGAAAAGGCTGGGCATGGTGGTTTATGCCTAAAATCCCAGCACTGTGGGAGGCCAAGGTGGACAGATAAGGAGTTCGAGACCAGCCTGACCAACATGGTGAAACCCCATCTGTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGCGCATGACTATAATCCCAGCTATTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGGGGCGGAGGT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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