Basic Information
VIS ID
TVIS30001349
Fusion event
HIV-RELN integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
103614373/103973926 (Hg38)
End
103615239/103973926 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
RELN
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-138-5p ; hsa-mir-10a-5p
Nearest miRNA
hsa-mir-10525/Upstream/1502395; hsa-mir-10399/Downstream/10679419;
Nearest TSS
ENST00000635602/Upstream/343790; ENST00000401970/Downstream/15590;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/527533, chr7-CpG: 122/Downstream/15152
Target sequence
GAAGGATAGAAACCAAAATCGTTTGGCTCCATACTCAACAGATATGTAATAACCTTATAGAAAACACACAAAAATGGAAACTCGACAAATTTCCCCAAAGATTTTGTCTTCTAAGAGAAATTTACTTGGACAGTGATGAACATACAAAGGGAACAGCAGCTGAGAATTCTGCATCTTCATTAAATTACATGTATTGATATCCCATAAGTTAAGAGGATCGGAGGCTCCAAACTTATGGAAATTAACATGAATGTT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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