Basic Information
VIS ID
TVIS30001352
Fusion event
HIV-MTREX integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
54658011/55362183 (Hg38)
End
54658559/55362183 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
MTREX
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10397/Upstream/189830; hsa-mir-103a-1/Downstream/146667;
Nearest TSS
ENST00000502646/Upstream/34653; ENST00000518955/Downstream/43069;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/54107, chr5-CpG: 23/Downstream/168599
Target sequence
ATTATGAAAACTGATTTTTTTTTATAGCTCATATCAAGTAATCAAAAATGTATCAAAAGAACTGCTGTCTTGGCTGGGCGTGGTGGCTCATGCCTGAAATACTAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCTAACATGGCGAAATCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCATGGCGGCACATGCCTGTAATCTCAGCTACTTGGGAGGCTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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