Basic Information
VIS ID
TVIS30001353
Fusion event
HIV-SLC25A25 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
130856690/128094411 (Hg38)
End
130857538/128094411 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLC25A25
miRNAs that regulate target gene
hsa-mir-647 ; hsa-mir-183-5p ; hsa-mir-8064 ; hsa-mir-604 ; hsa-mir-1273f ; hsa-mir-889-5p ; hsa-mir-96-5p ; hsa-mir-1271-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-4262 ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-670-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-3124-3p ; hsa-mir-1236-3p ; hsa-mir-205-5p ; hsa-mir-877-3p ; hsa-mir-4457 ; hsa-mir-501-5p ; hsa-mir-1972 ; hsa-mir-3660 ; hsa-mir-378a-5p ; hsa-mir-4267 ; hsa-mir-4526 ; hsa-mir-4793-5p
Nearest miRNA
hsa-let-7a-1/Upstream/224916; hsa-mir-12126/Downstream/150310;
Nearest TSS
ENST00000422679/Upstream/2947; ENST00000472769/Downstream/46;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/25741, chr9-CpG: 159/Downstream/33008
Target sequence
GTATTCAGTTCCCAAAGGATGCCGGTAAGCCAGACAGTAGGTGATACCTCATACTGGAAGGCGGCAGGTGTGTGGGAAAGGTGTAACTTGAGCAAGTTGAGCCCTAGCTAAATACAACCAAAAACGGTGTTTGTGTCACAGCTTCTGAATGCCTCTGTGAGAACTAGATTATGGAGGAACTAAAGCAGGCCTCGGGTTTCAGCCCTGATGCTTCACACCGGCCTTCTTGACACTCCAAGATCTGGGCACAACGCG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate