Basic Information
VIS ID
TVIS30001355
Fusion event
HIV-SRPK1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
35836607/35868830 (Hg38)
End
35837394/35868830 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
SRPK1
miRNAs that regulate target gene
hsa-mir-93-5p ; hsa-mir-16-5p ; hsa-mir-652-3p ; hsa-mir-186-5p ; hsa-mir-99a-5p ; hsa-mir-95-5p ; hsa-mir-3926 ; hsa-mir-3922-5p ; hsa-mir-4753-5p ; hsa-mir-7158-5p ; hsa-mir-6881-5p ; hsa-mir-6890-5p ; hsa-mir-7851-3p ; hsa-mir-619-3p ; hsa-mir-4802-3p ; hsa-mir-942-3p ; hsa-mir-6796-3p ; hsa-mir-99b-3p ; hsa-mir-99a-3p ; hsa-mir-548m ; hsa-mir-376a-5p ; hsa-mir-376a-2-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-3973 ; hsa-mir-1252-3p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-6882-3p ; hsa-mir-139-5p ; hsa-mir-22-3p ; hsa-mir-3156-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-1236/Upstream/204041; hsa-mir-10398/Downstream/753606;
Nearest TSS
ENST00000381078/Upstream/29989; ENST00000622903/Downstream/721;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/81693, chr6-CpG: 82/Downstream/51777
Target sequence
CTTTCGTAAGTATATTTAAACTTTTCCATAGTAAAAGGTTTTTTTAAATGTAAAAAAATATTCACTGAAGTGTTGTATCAATCTGGGTACAGAATTACGGATGTTTTGCATAACTAAGTCCAAATTCTCATTCATCCTCCCAGTCACTTCAAAACACCATTAAGGCAAGTTTAACTTACCACCCAACAAGCATTTCCAAGGTCAGCAATCTTCACCTTGAGCTTTTCTGCATTTTTTGGCTCAAGGGGATTAACA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate