Basic Information
VIS ID
TVIS30001357
Fusion event
HIV-TLK1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
171879145/171022635 (Hg38)
End
171879892/171022635 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
TLK1
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-28-5p ; hsa-mir-374b-3p ; hsa-mir-5696 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-1909-5p ; hsa-mir-4729 ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p ; hsa-mir-646 ; hsa-mir-5586-3p ; hsa-mir-503-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-1305 ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-4660 ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-4801 ; hsa-mir-4731-3p
Nearest miRNA
hsa-mir-128-1/Upstream/2439617; hsa-mir-10b/Downstream/4144998;
Nearest TSS
ENST00000437798/Upstream/68817; ENST00000495925/Downstream/32494;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/48437, chr2-CpG: 126/Downstream/137393
Target sequence
ATATAAGTGCCAGAAGTTTTATTTGAAAAACATAACCAATTTGTAATTGAAACAGGATTAGTCAAGAACCATCAGCACCAACACAAATGTATCTTTGCAGACCGAAGGAATCAGCTAAACAATTTACAGTCATCTCAATCTCTACTAAAACAAAAATCACATCCAACATGCCACCTGACACCATTTCTTTCTCTCTCTCTCCTTTGCTCCTTGCGATGTGGCATTCATCTCTCCTTGTGCCTCCGTTCTGAAGAG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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