Basic Information
VIS ID
TVIS30001358
Fusion event
HIV-TNKS integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
9449392/9591882 (Hg38)
End
9450340/9591882 (Hg38)
Orient
-
Location type
Intronic
Target gene
TNKS
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-324-3p ; hsa-mir-324-5p ; hsa-mir-142-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-4693-5p ; hsa-mir-3607-3p ; hsa-mir-1183 ; hsa-mir-1277-5p
Nearest miRNA
hsa-mir-3674/Upstream/543364; hsa-mir-10400/Downstream/149790;
Nearest TSS
ENST00000518652/Upstream/16875; ENST00000521039/Downstream/23408;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/35299, chr8-CpG: 60/Downstream/306785
Target sequence
GAATCTCAAGATATCACCTAATCAAGAAGTAGAAAATTACTCAGCTTCCTTATCCATGTAACACAGAGTAATATAAAAAAAAGTCAGACAGAATCAAGCCTTCTTCCAGTGAACTGCTTTGTCACTTCACACACGTTTCTTGAATATAATTAGACATCAGTGATAGACAATAAGAATACGTATGAAAGTGGACAAGATTATTGTTAGTTCCTACCACAGAGAACGTGGTACATGCTTAACTTCACACCTTACCTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate