Basic Information
VIS ID
TVIS30001362
Fusion event
HIV-TTBK2 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.2
Reference genome
GRCh37/hg19
Start
43165701/42873503 (Hg38)
End
43166500/42873503 (Hg38)
Orient
+
Location type
Intronic
Target gene
TTBK2
Nearest miRNA
hsa-mir-1233-1/Upstream/673837; hsa-mir-10393/Downstream/920156;
Nearest TSS
ENST00000557528/Upstream/132755; ENST00000570109/Downstream/34772;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/136082, chr15-CpG: 88/Downstream/46715
Target sequence
GGTACCTAACAGGGTCCACAGAGCAGGCAGAGAACTCTAGTACCAAACTATCCCAGAATTCACTATACATCTATTTATTCAAATAAGAGTAAAAAAAAATCAATTTAAGCAAGTTCAACAAGCACTATTCTCTCTGATAAAATAAATATGTTAGCTTAACTGGGGAATATCAGGATGCTGGTGTGAGTATCATAAGCAAGTTCTGAAGAGTCAGTGGCAAGTGCACCTGTAGTGTCTGAAAGCTGGGTTGTGGGG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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