Basic Information
VIS ID
TVIS30001363
Fusion event
HIV-TTLL5 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
76297653/75831310 (Hg38)
End
76298138/75831310 (Hg38)
Orient
-
Location type
Intronic
Target gene
TTLL5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-3121-3p ; hsa-mir-548c-3p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-7157-3p ; hsa-mir-5008-3p ; hsa-mir-6737-3p ; hsa-mir-6889-3p ; hsa-mir-545-5p ; hsa-mir-7845-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-4475
Nearest miRNA
hsa-mir-208a/Upstream/1351106; hsa-mir-1185-1/Downstream/1434908;
Nearest TSS
ENST00000550708/Upstream/28166; ENST00000557219/Downstream/5901;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/169739, chr14-CpG: 76/Downstream/150970
Target sequence
ACTATGCACACACAGTAAAGAAAAAATGTGATATGGGAACACAGGGAGAGTCTGCAAAGTGCTGAAACAGCATACCTGGCAGCTGCTAAAACAAAACTTCAAAGATTTGGCGTCTCTGAAAAGCCATCAGGCAGGACCCCACCCACTCCCCCTGCTAGCCACGGCTTCCCTGGGAGCTAGTACACGTAACCACTTCCGCATGTTTGGCTCTGTTCCCCAGAGTTACAGCAGCTCTAGAAGCCATGTCAGAACCTC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate