Basic Information
VIS ID
TVIS30001365
Fusion event
HIV-VPS13B integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
100277270/99265042 (Hg38)
End
100278183/99265042 (Hg38)
Orient
+
Location type
Intronic
Target gene
VPS13B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30e-5p ; hsa-mir-186-5p ; hsa-mir-3613-5p ; hsa-mir-4494 ; hsa-mir-499b-5p ; hsa-mir-4705
Nearest miRNA
hsa-mir-12123/Upstream/871304; hsa-mir-10400/Downstream/271594;
Nearest TSS
ENST00000518652/Upstream/108413; ENST00000522802/Downstream/10167;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/251271, chr8-CpG: 35/Downstream/628387
Target sequence
ATATTTTAAATAAATGTTCATTTCTTATTGCAGTATCTTCTGTACTCTTTGAGGATAGAAATCATTATTATTATTATTATTTGAAGTTTTCTTCTGCTCCTGGCTTTGTCTGTTTACCCCATGTTCCTTTTTTTATGTTTTAAAATAATATCTGCCTGTCACATTTGTGATTTCCATCTAATATTTAACAATCCTTCATATTGCAGAATGAAGTACAAAATAACTGAAACCTCTGTGTGAGGTTGGAACTTGTTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate