Basic Information
VIS ID
TVIS30001370
Fusion event
HIV-chr6 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.33
Reference genome
GRCh37/hg19
Start
30470217/30502440 (Hg38)
End
30471002/30502440 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-3143/Upstream/3354752; hsa-mir-10398/Downstream/81892;
Nearest TSS
ENST00000381078/Upstream/12928; ENST00000415195/Downstream/13826;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/12042, chr6-CpG: 20/Downstream/53069
Nearby gene
HLA-E(No orient, 8235)
Target sequence
ACCACAAAAATCAATTAATAAAAGCCATCTTTAATAAGTAGGCTTAATTGTATTGATTAAATTAAAAATTGTCTTGATTTAATAGGTTACATCTATGAAGCTTTGTAAACATCCTTCATGGTTGACTTAATTTAAAAATTTTAAGTTCTTAATATATTTTACTTTTGTCATCAAACTACAATTGCAATCACATAAATTATTAGATAATCTAATTGACTTTTTCTCTTGAAGTTGACATTTTTCTTTCAAATGGTA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate