Basic Information
VIS ID
TVIS30001376
Fusion event
HIV-AKAP7 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
131528702/131207562 (Hg38)
End
131529123/131207562 (Hg38)
Orient
-
Location type
Intronic
Target gene
AKAP7
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-24-3p ; hsa-mir-484
Nearest miRNA
hsa-mir-10398/Upstream/4722849; hsa-mir-1202/Downstream/584610;
Nearest TSS
ENST00000381078/Upstream/6735; ENST00000474850/Downstream/42597;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/71545, chr6-CpG: 42/Downstream/420385
Target sequence
GTAATTAAGCCATCTGACACCGGGAGATTCAAAAATAGTTTACAGAAACAATCTGCTTTATCTTGCACCAAAGATATTTTTAAAGTTTTGTCTGGAATAATCAAGGTTCACTGAATAACCAGGGCATCTACAAATGCCCTCTTTGTGGGATGAAGGAAGGAAGTGGCAGGGTAGTCTCCAGGCTTCTCTGTGC:TCTCCTTTGTTAGAATGAAGGAATATTCTTTAAAATGTAGAGCCCTTGCCTATTCTGTCTC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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