Basic Information
VIS ID
TVIS30001383
Fusion event
HIV-DNAH10 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
124312730/123828183 (Hg38)
End
124312942/123828183 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
DNAH10
Nearest miRNA
hsa-let-7i/Upstream/291649; hsa-mir-3612/Downstream/508998;
Nearest TSS
ENST00000382841/Upstream/47056; ENST00000497783/Downstream/7256;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/40145, chr12-CpG: 45/Downstream/108851
Target sequence
TGGCTCTGACCTAACTTGGCCAGAATCCCCTCTCAGGTTTGTTTTCTCTAAAATAAACCTGTTTTGACTGGCAAGCCACCTTTTGTGTTTCTTTCCTCTTTCTTTAATTCTTACGCTGTGTCCTCAGTCCCTCCCCAGGGTCATTCACCTTTCTTAGAGCGAAGGTCTCTGGCTCAGAGACAGGCGACTGTTTTGAGCTAGTTTTTTTTTTT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate