Basic Information
VIS ID
TVIS30001391
Fusion event
HIV-HSF5 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q22
Reference genome
GRCh37/hg19
Start
56559007/58481646 (Hg38)
End
56559963/58481646 (Hg38)
Orient
+
Location type
Intronic
Target gene
HSF5
miRNAs that regulate target gene
hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-4330 ; hsa-mir-4733-5p ; hsa-mir-5571-5p
Nearest miRNA
hsa-mir-10226/Upstream/145624; hsa-mir-1250/Downstream/656112;
Nearest TSS
ENST00000595228/Upstream/64051; ENST00000580769/Downstream/6738;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/129101, chr17-CpG: 117/Downstream/5847
Target sequence
TAAACCCATTCAACAAGTTACATATCTGTCATTCTATTTCTGTAGTTTAATTTCCTTTAAAGAATAAAGCACGCCAGCCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGTCCAAGAGTTCAAGATCAGCCTCAGCAACATGGTGAAACCCCATCTCTACAAAATATACAAAAATCAGCTGGGCACGATGGTGCATGCCTGTAATCCCAGCTACTCAGGAGGCTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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