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Viral Integration Site DataBase
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TVIS30001392
Basic Information
VIS ID
TVIS30001392
Fusion event
HIV-JAK1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
65411339/64945656 (Hg38)
End
65411429/64945656 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
JAK1
miRNAs that regulate target gene
hsa-mir-17-5p
;
hsa-mir-106b-5p
;
hsa-mir-128-3p
;
hsa-mir-20a-5p
;
hsa-mir-23b-3p
;
hsa-mir-15b-5p
;
hsa-mir-9-5p
;
hsa-mir-107
;
hsa-mir-30e-5p
;
hsa-mir-30d-5p
;
hsa-mir-30c-5p
;
hsa-mir-30a-5p
;
hsa-mir-30b-5p
;
hsa-mir-519d-3p
;
hsa-mir-93-5p
;
hsa-mir-20b-5p
;
hsa-mir-373-3p
Nearest miRNA
hsa-mir-12132/Upstream/365733; hsa-mir-101-1/Downstream/112099;
Nearest TSS
ENST00000473358/Upstream/66593;
ENST00000470888/Downstream/20848;
Nearest CpG islands
None/Target,
chr1-CpG: 111/Upstream/200101
,
chr1-CpG: 123/Downstream/20116
Nearest cancer related gene
JAK1
(OG, No orient, 0)
Target sequence
GGAACGAAGTTGACGGACAAACAAAAATGGGAGCAAACCTTCTCAATTTGTACCCTGTTATACTGGTTTGCTTTCTTTTTTTTTTTCTTT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Sample Information
×
Sample name
R1
Sample type
PBMC
Gender
Female
CpG Island Information
×
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