Basic Information
VIS ID
TVIS30001398
Fusion event
HIV-LMO7 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
76366214/75792078 (Hg38)
End
76367080/75792078 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13E
Target gene
LMO7
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-1297/Upstream/9573754; hsa-mir-1267/Downstream/1905934;
Nearest TSS
ENST00000623511/Upstream/3240; ENST00000526371/Downstream/12096;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/155001, chr13-CpG: 195/Downstream/1093109
Target sequence
AAAACAATCATTGGAAATACAAGGGATGTCCTATTCTGTGATAAACACCATAAGCAGTGACCTTCGCATTATTACCTTTTACTCACTTTACATTCCCTTCTAAATATGAGCATTTATAACATGCTCTTGGACATGATACATAGGCCAGCCAAATTAGTGTCCTATCTCTGAAATGCAATGCCAGGAATTCAAGTAGTCAATGATTTGCTGGAGTAAACAGAGTTCACTCTCTCACATACAAATGCATTCCACTGC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate