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Viral Integration Site DataBase
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TVIS30001402
Basic Information
VIS ID
TVIS30001402
Fusion event
HIV-NSMCE2 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
126274525/125262283 (Hg38)
End
126274779/125262283 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C
;
FRA8E
Target gene
NSMCE2
miRNAs that regulate target gene
hsa-mir-7151-3p
;
hsa-mir-5095
;
hsa-mir-1976
;
hsa-mir-3653-5p
;
hsa-mir-6747-3p
;
hsa-mir-6727-3p
;
hsa-mir-4722-3p
;
hsa-mir-4740-3p
;
hsa-mir-764
;
hsa-mir-6504-3p
;
hsa-mir-3159
;
hsa-mir-552-3p
;
hsa-mir-1303
;
hsa-mir-3188
;
hsa-mir-6866-5p
;
hsa-mir-877-5p
Nearest miRNA
hsa-mir-12123/Upstream/440225; hsa-mir-10400/Downstream/2533679;
Nearest TSS
ENST00000518652/Upstream/138139;
ENST00000521460/Downstream/89133;
Nearest CpG islands
None/Target,
chr8-CpG: 109/Upstream/170403
,
chr8-CpG: 216/Downstream/166946
Target sequence
GCGTGGTGGCAGGTGCCTATAGTCCCAGCTACTTGGGAGACTGAGGCAGGAAATGGCATGGACCTGGGAGGCAGAGCTTGCAGTGAGCAGAGATCGCGCCACTGCATTCCAGCCTGGGAGACAGAGTGAGACTCCCTCTCAAAAAATAAATAAATAAATAGTATACAATTTTGTGAAAGTATATGAGTCAAACTTTCCTTTAGTTTGCCATTCATTCATTCATCCATTTATTAGTATTCATCCATTTATTGTTC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Sample Information
×
Sample name
R1
Sample type
PBMC
Gender
Female
CpG Island Information
×
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