Basic Information
VIS ID
TVIS30001403
Fusion event
HIV-OXCT1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
41818735/41818633 (Hg38)
End
41819050/41818633 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
OXCT1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-100-5p
Nearest miRNA
hsa-mir-10397/Upstream/3261072; hsa-mir-103a-1/Downstream/12132871;
Nearest TSS
ENST00000502646/Upstream/23990; ENST00000505931/Downstream/24124;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/308084, chr5-CpG: 104/Downstream/50928
Target sequence
GCTTTTATTAATTTTTGGTTGTGTACCTGGATTTTCAAGGGGCCTAGTAAAAGGCCAGATATTTGCATATGTTCTAATATTAGGAGGCTGCCATATGCTGCATGCTCATACTACACTAATACATGGAAAAACGTGTTTATAAGACAAAAATTAACAAAAGGGGTCAATGAATCATATTTATCACTTTTTCCCACATTTCTTACTTAAATCATTTATATAAGCCATGACTTTAAGATGCCTTCTTTTAGCTTTGTC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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